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Obviously, trazodone carries a huge number of risks and comes with plenty of side effects, especially when used as a sleep aid.

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The efficacy of trazodone has been demonstrated in both inpatient and outpatient settings and for depressed patients with and without prominent anxiety.

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Trazodone is a member of the phenylpiperazine antidepressants drug class and is commonly used for anxiety, depression, fibromyalgia, and others.

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Because priapism has been reported to occur in patients receiving desyrel trazodone hydrochloride , patients with prolonged or inappropriate penile erection should immediately discontinue the drug and consult with the physician see warnings .

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This conclusion is supported by the following observations 1 recombinant cyp2d6 catalyzed-formation of m4 in incubations of m -cpp; 2 formation of m4 was strongly inhibited by quinidine, a specific cyp2d6 inhibitor, in both incubations of m -cpp and trazodone; and 3 concentration-dependent inhibition of formation of m4 by quinidine.

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The results constitute the first report on bioactivation of m -cpp, a major circulating metabolite for several antidepressant drugs including trazodone, nefazodone, and etoperidone.

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see warnings and precautions trazodone hydrochloride has been associated with the occurrence of priapism.

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