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mycosis fungoides cutaneous t cell lymphoma therapy with methotrexate as a single agent appears to produce clinical responses in up to 50 of patients treated.

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penicillins may decrease the elimination of methotrexate, so increase the risk of toxicity.
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In one study, etoricoxib 120 mg had no effect, but in the other study, etoricoxib 120 mg increased methotrexate plasma concentrations by 28 and reduced renal clearance of methotrexate by 13 .

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